Fade Fave: Gout
Fade Skinny: Seminar on gout, a common arthritis caused by deposition of monosodium urate crystals within joints after chronic hyperuricaemia. It affects 1—2% of adults in developed countries, where it is the most common inflammatory arthritis in men. Diet and genetic polymorphisms of renal transporters of urate seem to be the main causal factors of primary gout. Gout and hyperuricaemia are associated with hypertension, diabetes mellitus, metabolic syndrome, and renal and cardiovascular diseases. Non-steroidal anti-inflammatory drugs and colchicine remain the most widely recommended drugs for treatment of acute attacks. Oral corticosteroids could be an alternative. Patient education, appropriate lifestyle advice, and treatment of comorbidities are an important part of management of patients with gout.
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